Abstract Background The deregulated alternative splicing of key glycolytic enzyme, Pyruvate Kinase muscle isoenzyme (PKM) is implicated in metabolic adaptation of cancer cells.The splicing switch from normal PKM1 to cancer-specific PKM2 isoform allows the cancer cells to meet their energy and biosynthetic demands, thereby facilitating the cancer ce
Pearlitic steel experiences excessive corrosion in a hot and humid atmosphere.The multiphase Test Kits bainitic/martensitic structure was developed for a better combination of strength and ductility, especially rolling contact fatigue, but little attention to corrosion has been investigated.Corrosion behaviors of multiphase steels obtained from bai
Traditional methods for assessing the stability of rubble mound breakwaters (RMBs) often rely on 2.5D data, Rubber Hose Collar which may fall short in capturing intricate changes in the armor units, such as tilting and lateral shifts.Achieving a detailed analysis of RMB geometry typically requires fully 3D methods, but these often hinge on expensiv
Impaired decision-making is a core problem in several psychiatric disorders including attention-deficit/hyperactivity disorder, schizophrenia, obsessive compulsive disorder, mania, drug addiction, eating disorders, and substance abuse as well as in chronic pain.To ensure progress in the understanding of the neuropathophysiology of these disorders,